Top Verified NGOs, Charities and Non-profits (General) in South Africa – Leading Directory-Listing

The AIDS Legal Network (ALN) is a human rights organisation committed to the promotion, protection and realisation of fundamental rights and freedoms of people living with, and affected by, HIV and AIDS. Founded in 1994, our focus has been to respond to both the legal and ethical challenges presented by HIV. We do this by providing human rights and legal literacy training, by documenting and responding to rights violations and abuses through our Legal Advice Desk, and by advocating for law reform both nationally and internationally.

Our mission is to pursue excellence in research in the prevention, treatment and training of HIV and related diseases. The DTHF aims to impact health policy through both clinical and operational research by way of accredited peer-reviewed publications, guidance to local and national government, and community education and feedback. The DTHF health services and implementation research include vaccine research, scale up of community HIV treatment, behavioural research, community based disease screening, a major project on TB transmission, diagnostics, treatment adherence, training of health professionals in HIV and TB management, and a range of novel HIV preventative research in young women, adolescents, and key populations. Our public benefit status enables us to raise money for additional community projects such as our mobile units and a youth wellness centre.

Lawyers for Human Rights is an independent human rights organisation with a 38-year track record of human rights activism and public interest litigation in South Africa.

MAWU was the first union formed in Durban from the General Factory Workers Benefit Fund. Back then it was illegal for black workers to belong to a registered trade union so workers joined Benefit Funds – a cover for trade unions. Thousands of workers joined the fund after the Durban strikes in 1972 and 1973. MAWU was formed in 1973, and the Transvaal branch in 1975.

The National Union of Mineworkers was founded in 1982. Its birth was facilitated by comrades Cyril Ramaphosa who rose to be its first General Secretary, James Motlatsi who turned to be its first President, and Elijah Barayi who became its Vice President and later the President of Cosatu in 1985 when the federation was formed.

The South African Transport and Allied Workers Union (SATAWU) was formed in 2000 after a series of negotiations and small-scale mergers by unions in the transport industry. SATAWU organises workers in the transport as well as security and cleaning sectors. We have members in diverse sectors including railways, harbours, parastatals, aviation, passenger transport (buses and taxis) freight and logistics (trucking), contract cleaning and security.

4‑Paws is a Cape Town–based NPO providing veterinary care, education and advocacy to under‑resourced communities in South Africa. Founded in July 2006 in Cape Town as a registered NPO, 4‑Paws works to improve the lives of under‑privileged and feral animals in squatter communities through veterinary outreach (vaccination, spaying/neutering, tick/flea control), wellness education and advocacy. Partnerships with local NSPCA and shelters, unique Responsible Pet Ownership guide, campaigns against dog and cat meat trade and big‑cat trade, active in Western Cape and broader SA.

AFR100 is a continent‑wide initiative coordinating restoration of degraded land in Africa, supporting food security and climate resilience. Launched in December 2015 as a pan‑African partnership across 34 countries to restore 100 million hectares of degraded land by 2030. Programme supports food security, climate resilience, poverty reduction. Managed via NEPAD/AU Secretariat, technical and finance partners, TerraFund financing, FAO‑led restoration projects (2024‑2027). Unique scope: continent‑wide ecosystem restoration linked to Bonn Challenge and Agenda 2063.

AFFT is a Johannesburg‑based NPO feeding over 2,700 disadvantaged children daily in preschools and schools, improving nutrition and school attendance. Established in 2006, AFFT is a volunteer‑driven NPO (PBO 9300247131) providing daily school‑feeding services on the West Rand of Johannesburg. Currently feeds >2,700 children daily at 47 preschools, 6 schools, multiple community projects and 80 foster‑care families. Mission: improve nutrition, attendance, concentration. Also extends wrap‑around support including educational supplies.

Formerly Africa Foundation, now Wild Impact globally, supporting community development and conservation projects linked to &Beyond lodges. Formerly Africa Foundation (registered in South Africa, UK and USA), for 32 years partner of &Beyond in community and conservation development. In July 2024 rebranded to Wild Impact to reflect expansion beyond Africa. Focus remains community development, livelihoods, conservation education adjacent to safari lodges. Unique: tourism‑linked philanthropy, community‑led star projects funded by lodge guests.

ADHOPE is a Johannesburg‑based NGO since 2008 providing health, HIV‑AIDS and settlement support to African nationals and migrants in South Africa. Founded in 2008 in South Africa, ADHOPE supports African nationals—especially migrants and people living with HIV/AIDS—and offers integrated health services, early intervention, prevention partnerships with public/private sector, development and settlement support. Multi‑disciplinary NGO rooted in Ubuntu ethos across Gauteng.

Community beekeeping social enterprise empowering rural families in Western Cape through training, honey production and environmental conservation. African Honey Bee is a Christian social enterprise founded (circa 2018–2020) to empower rural families in impoverished areas of the Western Cape through sustainable beekeeping. They train families to build their own hives and equipment, form self‑help savings groups, manage hives, extract and sell honey. Their Honeybee Guardians programme creates income and conserves biodiversity, particularly Capensis honeybees. Offers community upliftment, food production, environmental education, and faith‑based support.

South Africa‑based African Parks leads long‑term park rehabilitation and conservation partnerships with governments and communities across multiple African countries. African Parks is a nonprofit conservation organisation headquartered in Johannesburg (Bryanston), South Africa. Established in 2000 to manage and rehabilitate national parks in partnership with governments and communities. Currently manages multiple parks across 10 African countries covering over 12 million hectares. Unique model: long‑term public‑private partnership and community engagement. Focus: biodiversity conservation, wildlife protection, park rehabilitation, governance training and tourism development.

Pan‑African entrepreneurship nonprofit based in Johannesburg empowering young people via mentorship, networks and trade opportunities. Founded in 2010 and headquartered in Johannesburg, Africa’s Young Entrepreneurs (A.Y.E.) is a nonprofit network led by founder Summy Smart Francis. It unites millions of African entrepreneurs (over 12 million members), offering mentorship, networking, business development and intra‑African trade facilitation. Hosts the student branch AYESA launched in 2015. Unique scale: pan‑African entrepreneurship ecosystem linking youth, investors, mentors and governments.

Johannesburg‑based Afrika Tikkun Services offers vocational training, recruitment and youth empowerment services in under‑privileged urban communities. Afrika Tikkun Services is part of Afrika Tikkun NPC, offering integrated youth development: skills training, recruitment, placement, BB‑BEE/SDF/EE consultancy. Based in Randburg, Johannesburg. It provides vocational training, placement services, youth empowerment across under‑resourced urban communities. Founded under Afrika Tikkun umbrella (est. 1994), the services arm launched later. Unique: holistic youth empowerment, alignment with national and corporate B‑BBEE compliance.

ARASA is a Cape Town‑based regional NGO founded in 2002, advocating HIV/AIDS rights and human rights across Southern and East Africa through policy, capacity building and coalition partnerships. ARASA was established in 2002 and has a regional office in Cape Town, South Africa. It is a civil society partnership working across Southern and East Africa in 18 countries to advance HIV/AIDS and human rights advocacy, capacity building and policy research. Programmes include advocacy for bodily autonomy, key populations and gender equality. Unique: regional coalition model combining health, law and human rights with grassroots activism and policy influence.

The AIDS Foundation of South Africa (AFSA), founded in 1988, serves as a national capacity‑building and funding NGO supporting community‑based HIV, TB & STI interventions across South Africa. Established in 1988 as the first registered AIDS NGO in South Africa, AFSA works through CBO partnerships to support HIV, TB and STI education, prevention and social support. Key programmes include adolescent and youth, sex worker advocacy, people with disabilities, orphans & vulnerable children, rights and advocacy & small projects support. Focus on community systems strengthening and structural drivers of HIV. Active across KwaZulu‑Natal and nationally via partner organisations. Unique for its early founding and capacity-building backbone for grassroots HIV response.

A branch of the global AIDS Healthcare Foundation, AHF South Africa delivers HIV, STI and TB care to 61 facilities across four provinces, including Johannesburg and Durban, since 2002. AHF South Africa began operations in 2002 with its first clinic in Umlazi. Since then, it has expanded to support 61 health facilities across four provinces (KwaZulu‑Natal, Eastern Cape, Gauteng). Provides HIV, STI and TB services via direct delivery, training, mentoring, M&E, equipment and infrastructure support. Launched ‘Food for Health’ in 2021. Unique as branch of the global AIDS Healthcare Foundation—the world’s largest HIV/AIDS care provider—with community programming embedded in national health systems.

Alliance of NPO Networks (ANNET), founded in 2020, is a national apex body coordinating over 22,000 non‑profits in South Africa to strengthen advocacy, sector policy and collaboration. Formed in April 2020 as an apex network body unifying major NPO networks (SANGOCO, SACONO, SANPOF, NANPOC). Represents over 22,500 non‑profits, advocating for a cohesive sectoral voice in policy, legislative frameworks, capacity building and collaboration. Engages government, donors and civil society to promote enabling environments for grassroots NPO activity. Unique national coordination & advocacy role.

Amnesty International South Africa, based in Johannesburg, is the local chapter of the global human‑rights NGO, campaigning for civil, political, social and economic justice through research and advocacy. Amnesty International South Africa is part of the global human rights movement founded in 1961. The South African section works on rights protection including freedom of expression, gender and LGBTI rights, economic & social justice, criminal justice reform and accountability. Conducts research, legal advocacy, public campaigns and grassroots mobilisation. Unique for combining international legal standards with local activism. Active countrywide, with significant impact on policy and public discourse.

The Animal Anti-Cruelty League provides nationwide animal welfare, rescue, and educational services across South Africa. The Animal Anti-Cruelty League (AACL) is one of South Africa’s oldest animal welfare organizations, established in 1956. It provides shelter, veterinary care, and education, and investigates animal cruelty. With branches nationwide, AACL promotes responsible pet ownership and enforces animal welfare legislation through its inspectorate.

Animal Welfare Society Helderberg, established in 1949 and based in Gordon’s Bay, provides animal rescue, veterinary care, adoption and anti‑cruelty services across the Helderberg region. Founded in 1949 (as Hottentots‑Holland Animal Welfare), and relocated to Gordon’s Bay in 2011. Provides shelter, veterinary care, adoption services, rescue and cruelty investigations across Somerset West, Strand, Gordon’s Bay, Macassar and Grabouw. Offers sterilization, vaccination clinics, community education and animal law enforcement. Unique local rescue society with decades‑long presence in Helderberg region.

Animal Welfare Society of South Africa, based in Philippi, Cape Town, offers adoption, vet care, rescue and cruelty investigation services with mobile response and community outreach. Founded locally in Philippi, Cape Town, the Animal Welfare Society of South Africa (AWS of SA) provides veterinary services, adoption, rescue, cruelty investigations, sterilization clinics, thrift shop support and community education in the Philippi region. Serving under-resourced suburbs in Western Cape, unique for its clinic and mobile emergency response model with local community integration since mid-20th century.

Based in Johannesburg, Anova Health Institute advances public health in South Africa through research, HIV/TB programmes and capacity building across sectors. Anova Health Institute, headquartered in Johannesburg, is a public-health and research NGO established in early-2000s. It supports HIV, STI and TB programmes, harm-reduction for key populations, community systems strengthening, health worker training and operational research. Active nationally and across Africa. Unique as evidence-driven institute linking research, training and service delivery in South Africa.

Ashraful Aid is a Sandton-based humanitarian NGO active over 25 years, delivering food, water, health and social welfare services across South Africa and globally using zakat-based support. Established over 27 years ago in Johannesburg, Ashraful Aid is an international humanitarian NGO delivering food, water, healthcare, social welfare, school support, children's and elderly homes, and disaster relief across South Africa (Sandton, Lenasia, Cape Town, Durban) and internationally. Unique for faith-based, zakat-funded model with broad community reach in multiple countries.

Beyond Zero, headquartered in East London, Eastern Cape, supports HIV and TB elimination in South Africa through technical assistance, advocacy and community programmes. Founded in early 2000s, Beyond Zero is a South African non-profit focused on eliminating new HIV infections and eradicating TB by strengthening health systems and community advocacy. Based in East London (HQ), runs programmes in HIV prevention, key populations, adolescent health, transgender and MSM outreach, community systems strengthening across South Africa. Unique for its indigenous, data-driven technical assistance embedded in public health systems.

CARE South Africa, part of CARE International, implements health, livelihood, climate and women's empowerment programmes nationally through local partnerships. CARE South Africa is the national member of CARE International, delivering emergency relief and long-term development programming in health, food security, economic development, women's empowerment, climate resilience and education. Works through local partners in South Africa and Lesotho. Unique as part of global confederation operating local autonomy, delivering humanitarian and development services aligned to CARE’s poverty-alleviation mandate.

CART is a rural sustainability hub in Eastern Cape teaching appropriate technologies and self-reliant living-skills for poorer communities. Founded in 1994 in Sicambeni Village, CART is a sustainable-technology and life-skills centre. It teaches appropriate rural technologies such as water purification, compost sanitation, solar power, garden beds, and HIV nutrition support. Unique for serving as a replicable model in one of South Africa’s poorest districts, empowering rural communities through hands-on training and local infrastructure.

CHOC supports children with cancer and their families through nationwide accommodation, nutrition, and psychosocial services since 1979. Founded in 1979 by parents of children with cancer, CHOC offers holistic family support including accommodation lodges, nutritional aid, Carebags, transport, and psychosocial counselling. Operating national and regional offices, it serves over 1,700 children annually and provides 32,000+ bed-nights. Unique parent-driven model supports families integrated into hospital cancer treatment pathways.

CHOSA supports community-based organisations caring for orphaned and vulnerable children through grants, mentoring, and capacity building. Founded around 2006, CHOSA supports grassroots community-based organisations (CBOs) caring for orphaned and vulnerable children. It provides funding, mentorship, capacity-building, and exchange programmes focused on under-resourced communities like Gugulethu and Khayelitsha. Unique for empowering CBOs to develop local child-welfare solutions.

CHOC maintains regional offices in multiple provinces providing accommodation, support, and transport for families affected by childhood cancer. CHOC operates a national network of regional offices in Gauteng, KwaZulu-Natal, Eastern Cape, and Free State. Each office delivers tailored services such as lodging, psychosocial support, and transportation for children undergoing cancer treatment. Unique national network of locally operated, regionally embedded offices.

CBM is a global NGO supporting people with disabilities through eye care, rehabilitation, education and advocacy in South Africa and across Africa. Founded in 1908, CBM is an international Christian development NGO that supports people with disabilities. It works in 21 African countries including South Africa, delivering services in eye health, inclusive education, rehabilitation, neglected tropical disease control, and livelihoods. CBM partners with local organisations and advocates for disability-inclusive policies and community development. Unique for its scale, heritage and disability focus.

Conservation International South Africa advances biodiversity and climate resilience through science-led programs and partnerships from offices in Johannesburg and Cape Town. Conservation International South Africa (CI-SA), established in 1992, operates with headquarters in Johannesburg and a satellite office in Cape Town. It advances climate resilience, biodiversity restoration, and sustainable livelihoods through science-led conservation, policy advocacy and private sector partnerships. CI-SA supports marine protection, climate-smart agriculture, freshwater ecosystems and green economy jobs. Unique for its integration of local action with global conservation goals.

Cotlands is a national ECD nonprofit offering play-based education, toy libraries, and literacy services in underserved communities since 1936. Cotlands, founded in 1936, is a national non-profit pioneering play-based early childhood education (ECD) in under-resourced communities. Originally an orphanage, Cotlands now delivers mobile toy libraries, playgroups, online courses and literacy initiatives across Gauteng, Western Cape, Eastern Cape, KwaZulu-Natal and Mpumalanga. Unique for integrating play into scalable ECD delivery models. Headquartered in Kensington, Johannesburg.

DAWA is a feminist youth-led NGO based in South Africa supporting girls and young women’s rights, leadership and livelihoods across Africa. Founded in 2019, DAWA is a South Africa– and Zimbabwe–based youth-led feminist movement focused on adolescent girls and young women (AGYW) across Southern and East Africa. It promotes sexual and reproductive health and rights, economic empowerment, leadership, peacebuilding and digital advocacy. DAWA acts as a resource and networking hub for AGYW-led initiatives. Unique for its intersectional, intergenerational and cross-border youth focus.

DGMT is a Cape Town-based trust investing in education, innovation, and social development through strategic philanthropy since 1979. The DG Murray Trust, founded in 1979, is a Cape Town–based public innovator that invests in social development and civil society growth. DGMT supports initiatives in early childhood development, education, health, youth employment, innovation, and policy research. Its portfolio includes literacy campaigns, mental wellness, digital access and food security. Unique for combining strategic philanthropy with scalable innovation.

Dogtown SA is a Gauteng-based rehabilitation and adoption centre providing specialized care and rehoming services for abused dogs. Dogtown SA is a non-profit rescue and rehabilitation centre located near Pretoria. It is the only certified dog behaviour rehabilitation facility in South Africa, specializing in rehoming misunderstood, abused or traumatized dogs. Each dog receives individualized training and behavior modification support from accredited trainers. Dogtown also runs adoption services, senior pet sanctuary and advocacy for responsible pet ownership.

Earthlife Africa Johannesburg is an environmental justice NGO advocating for sustainable energy, anti-nuclear policy and climate justice in South Africa. Founded in 1988, Earthlife Africa Johannesburg is a South African environmental justice NGO focusing on sustainable energy, anti-nuclear campaigning, climate justice and community empowerment. It runs climate and energy literacy workshops, advocacy, litigation and awareness campaigns. Unique for combining environmental science with grassroots mobilisation and legal action.

Empilisweni is a Ladybrand-based NGO offering HIV/AIDS care, counselling and support to orphans and vulnerable families in the Free State. Empilisweni HIV-AIDS & Orphan Care Centre is a non-profit organisation based in Ladybrand, Free State. It provides home-based care, nutrition, counselling, and support services to people living with HIV/AIDS and orphaned/vulnerable children. Also delivers early childhood education and social support to families. Unique for its deep community-rooted response to HIV/AIDS and orphan care in rural South Africa.

Epilepsy South Africa provides national services for persons with epilepsy and other disabilities, including training, support and advocacy since 1967. Epilepsy South Africa is the only national organisation in the country providing comprehensive services to persons with and affected by epilepsy and other disabilities. Founded in 1967, it operates across seven provinces with services including accommodation, training, advocacy, public education and employment development. Unique for its combination of neurological health support and community-based disability empowerment.

Equal Education is a youth-led movement campaigning for equal, quality education in South Africa through activism, research and legal advocacy. Founded in 2008, Equal Education is a movement of learners, parents, teachers and community members working for quality and equality in South African education. It uses research, legal advocacy, youth leadership, and mass mobilisation to campaign for infrastructure, textbooks, school safety, and equitable education funding. Unique for its grassroots youth organising and evidence-based public campaigns for education rights.

ERAO is a Johannesburg-based NGO promoting equality, legal rights, and civic education across South Africa and the African continent. Equality Rights Africa Organization (ERAO), based in Johannesburg, is a non-profit focused on promoting human rights, gender justice, social inclusion, and youth empowerment. It offers legal education, civic training, gender-based violence (GBV) advocacy and policy engagement throughout Southern Africa. Unique for blending grassroots legal education and pan-African civic advocacy.

FOUR PAWS South Africa promotes animal welfare through rescue, advocacy, and education with a base in Cape Town. FOUR PAWS South Africa, part of the global FOUR PAWS Animal Welfare Foundation founded in 1988, operates out of Cape Town. It works to improve the lives of wild, stray, and farmed animals through rescue, advocacy, public education, lobbying, and the creation of species-appropriate sanctuaries. They actively campaign against animal cruelty in wildlife tourism, fur trade, and factory farming. Unique for combining global advocacy with local action and sanctuaries.

GroWorth is a Johannesburg-based nonprofit empowering youth and women through skills training and entrepreneurship development. GroWorth is a South African nonprofit organization that empowers individuals, especially women and youth, through skills development, entrepreneurship training, and socio-economic upliftment. Its programs include vocational training, financial literacy, and small business support. Based in Johannesburg, it partners with government and private sector to build sustainable livelihoods. Unique for integrating personal growth with enterprise development to combat poverty.

Guardians of the Deep is a Cape Town NGO leading ocean education and marine conservation through youth engagement and advocacy. Guardians of the Deep NPC is a Cape Town–based marine conservation NGO that educates and mobilizes communities and schools to protect marine ecosystems. It runs youth programs, ocean literacy projects, clean-up events, and conservation activism. Founded by ocean advocate Zandile Ndhlovu, also known as the Black Mermaid. Unique for centering African identity in ocean conservation and building community stewardship of marine environments.

Habitat for Humanity South Africa builds affordable homes and empowers communities through volunteer-based housing programs. Habitat for Humanity South Africa, part of the global Habitat network founded in 1976, works to provide decent shelter through partnerships with low-income families. Operating in communities across South Africa, it engages in housing construction, disaster recovery, and community development. Unique for mobilizing volunteers and empowering families to build safe, affordable homes.

Help A Child SA supports vulnerable children in KwaZulu-Natal through education, family support and community development programs. Help A Child South Africa is part of the global Help A Child network that supports vulnerable children and families through education, community development, and child protection initiatives. It works in KwaZulu-Natal providing early childhood development, youth skills programs, family strengthening and psychosocial care. Unique for its holistic approach combining child sponsorship, parenting support, and community resilience.

HelpAge International South Africa promotes the rights, health and dignity of older people through advocacy and local partnerships. HelpAge International is a global network promoting the rights and well-being of older people. Its South African office, based in Johannesburg, partners with local organisations to improve health, income security, care and protection for the elderly. HelpAge South Africa conducts advocacy, research, and program implementation to ensure older people are included in development agendas. Unique for its focus on ageing population needs and rights.

Hope SA Foundation provides food, clothing, education, and skills development to vulnerable communities across South Africa. Hope SA Foundation is a nonprofit focused on poverty alleviation and community upliftment. Based in Alberton, Johannesburg, it provides food relief, hygiene packs, clothing, education, and emergency aid to underserved communities. It also runs youth mentorship, mental health support, and skills training. Unique for rapid-response community interventions during national crises such as floods and pandemic lockdowns.

Hospivision is a Pretoria-based NPO offering counselling, trauma care and emotional support to patients and staff in South African hospitals. Founded in 1997, Hospivision is a faith-based NPO providing psycho-social and spiritual care in hospitals and healthcare institutions. Based at Steve Biko Academic Hospital in Pretoria, it works in partnership with government hospitals to support patients, families and medical staff. Programs include counselling, trauma debriefing, terminal illness support, pastoral care, and community development. Unique for integrating compassion-based support into public healthcare environments.

HURISA promotes human rights, civic education, and democratic development across Southern Africa through advocacy and training. Established in 1994, HURISA promotes human rights, democracy and peace across Southern Africa. It offers civic education, leadership training, constitutional literacy, anti-corruption advocacy and election monitoring. HURISA engages with civil society, youth and government actors to strengthen democratic governance and accountability. Unique for combining education, advocacy and grassroots mobilization.

Ikamva Labantu is a community development organization providing ECD, elder care, nutrition and social services in Cape Town townships. Ikamva Labantu is a Cape Town-based NGO founded in the 1960s. It supports vulnerable communities through early childhood development, elder care, nutrition, education, and social entrepreneurship. Ikamva runs programs in townships such as Khayelitsha and Gugulethu, reaching thousands with holistic support services. Unique for its long history and deep community partnerships.

IkamvaYouth equips disadvantaged South African youth with mentoring, tutoring and career guidance to access higher education and jobs. Established in 2003, IkamvaYouth is a learner-mentorship NGO equipping youth from disadvantaged communities in Gauteng and Western Cape with academic support, career guidance, and digital literacy to access tertiary education and employment. Operates branch centres in Cape Town, Pretoria, Durban, and informal settlements. Unique peer tutoring model linking alumni volunteers and school-based branches.

iMentorU Foundation provides mentorship, career readiness and leadership development to South African youth via nationwide provincial branches. Founded in 2017, iMentorU is a South African youth mentorship and leadership NGO focused on facilitating career readiness, skills coaching and university placement support for learners across provinces. Partners with schools, universities and corporates. Unique for nationwide regional branch structure in Eastern Cape, Free State, Limpopo, KZN, Mpumalanga and North West.

Inkcubeko Nezobugcisa is a Cape Town NPO supporting rural youth through arts, culture and creative livelihoods in the Garden Route since 2019. Founded in November 2019, Inkcubeko Nezobugcisa (Culture & Art in isiXhosa) is a Cape Town based NPO promoting arts, culture and innovation among youth in George and the Garden Route. Offers workshops, community events and artist promotion to support livelihoods via creative industries. Unique for combining art with Xhosa culture and rural youth empowerment.

IRD South Africa delivers evidence-based health programme design, digital tools and research across infectious and non-communicable diseases through partnerships nationwide. IRD South Africa NPC, part of the global IRD group, operates since early 2000s in Pretoria. Focuses on integrated health systems strengthening, infectious & non-communicable disease programmes, immunization, mental health, early childhood development, digital health tools and health research. Partners with government and communities across rural and urban areas. Unique for blending research, technology and service delivery at scale.

Diabetes South Africa, established 1969 and IDF member since 1976, offers diabetes advocacy, education and community wellness across South Africa. Founded in 1969, Diabetes South Africa (member of the International Diabetes Federation since 1976) is the national association representing people with diabetes. Offers advocacy for healthcare policy, community education, screening, camps for type‑1 youth, wellness groups, workshops and support networks via branches in all provinces. Unique for national wellness groups, camp programmes and linkage to IDF global networks.

ISAMUN 2020 is a South African Model UN educational program promoting diplomacy, leadership, and global awareness among youth. Isamun (International South African Model United Nations) 2020 is an educational NGO initiative simulating UN debates for high school students. Based in South Africa, it promotes youth diplomacy, public speaking, and global awareness. The 2020 event aimed to give learners an opportunity to represent UN countries and negotiate global issues, fostering leadership and critical thinking. Unique for its inclusive, youth-led model UN format.

iSimangaliso Wetland Park is South Africa's premier UNESCO site, protecting biodiversity and promoting sustainable tourism and community upliftment. iSimangaliso Wetland Park is South Africa’s first UNESCO World Heritage Site, managed by the iSimangaliso Authority. It operates as a conservation and eco-tourism nonprofit entity. Located on the east coast of KwaZulu-Natal, the park encompasses 332,000 hectares of wetlands, marine reserves, coastal forests and savannahs. Its mission includes biodiversity preservation, local employment, eco-tourism, and environmental education. Unique for combining ecological protection with sustainable development goals.

Islamic Relief South Africa delivers humanitarian aid and development support to vulnerable communities across the country and globally. Islamic Relief South Africa, established in 2004, is part of the global Islamic Relief Worldwide humanitarian network. It provides emergency aid, education, healthcare, orphan support, food security and sustainable development programs in South Africa and abroad. Based in Cape Town with outreach across provinces. Unique for its faith-based, community-oriented humanitarian approach.

Islamic Relief Worldwide is a global humanitarian organization with South African offices, delivering poverty alleviation and emergency aid globally. Islamic Relief Worldwide is a leading international humanitarian organization founded in 1984 in the UK. It operates in over 40 countries, including South Africa. Its mission focuses on alleviating poverty, responding to emergencies, and empowering communities. Services include water and sanitation, education, sustainable livelihoods, and disaster relief. It has a strong South African presence through Islamic Relief SA.

Iziko Labantu Youth Development Organization empowers youth in Mdantsane, Eastern Cape, through training, sports, and career development. Iziko Labantu Youth Development Organization is a grassroots nonprofit based in Mdantsane, Eastern Cape. It aims to empower youth through skills development, sports programs, career guidance, entrepreneurship training, and HIV/AIDS awareness. Active in local schools and townships, it bridges opportunity gaps in disadvantaged communities. Unique for its bottom-up, locally driven youth empowerment model.

Jamiatul Ulama South Africa is a Johannesburg-based Islamic NGO offering education, halal services, and social welfare since 1923. Established in 1923, Jamiatul Ulama South Africa is one of the oldest and most prominent Islamic NGOs in the country. Headquartered in Johannesburg, it offers services in religious guidance, education, halal certification, social welfare, advocacy, media, and disaster relief. The organization has regional offices across multiple provinces and plays a vital role in Muslim community development.

Jhpiego South Africa partners with the health sector to deliver HIV, maternal and child health solutions via training and innovation. Jhpiego is an international, nonprofit health organization affiliated with Johns Hopkins University. Its South Africa office is based in Johannesburg. Jhpiego works with the South African Department of Health to improve maternal and child health, strengthen HIV and TB programs, and scale innovations in primary healthcare. They provide technical assistance, training, research and service delivery.

Justice Desk Africa is a Cape Town NGO promoting human rights, leadership, and justice education in South Africa and beyond. Justice Desk Africa is a human rights nonprofit founded in 2013 in Cape Town. It empowers ordinary people through education, training, and community activism. Their programs include anti-gender-based violence initiatives, youth ambassador training, leadership development, and civic education. The organization serves South Africa and surrounding countries, working with schools, community leaders and the justice system.

Khula Development Group supports at-risk primary learners in Western Cape with interventions preventing school dropout and improving education outcomes. Khula Development Group is a nonprofit based in Paarl, Western Cape, focused on reducing school dropout rates among primary learners in underserved communities. Since 2005, Khula has partnered with over 20 schools and local government departments to offer early intervention, home visits, parental support, and reintegration of dropouts. Targeting learners from Grade R–4, Khula is unique for its research-based, child-centric approach and community collaboration.

Khulisa Social Solutions is a Johannesburg-based NGO offering national programmes in youth development, justice reform, and community upliftment. Founded in 1997, Khulisa Social Solutions is a national nonprofit organisation based in Johannesburg that provides social interventions in education, justice, mental health, restorative practices, and community development. Operating in multiple provinces, it partners with government, corporates, and communities to uplift vulnerable populations, particularly youth and ex-offenders. Khulisa is known for pioneering rehabilitation and diversion programmes, and for its holistic and scalable model.

Kleinmond Animal Welfare Society (KAWS) rescues and rehomes stray animals in the Western Cape and provides sterilization and outreach services. KAWS is a registered animal welfare NGO operating in Kleinmond and surrounding areas of the Overstrand in the Western Cape. They rescue, rehabilitate, sterilize and rehome stray and abused animals, and also conduct community outreach and education. Known for their hands-on work in underserved rural and semi-rural communities and partnerships with local municipalities.

Kloof and Highway SPCA in KwaZulu-Natal rescues and protects animals from cruelty while offering vet and adoption services. Kloof and Highway SPCA, based in Kloof, KZN, is one of the largest SPCAs in South Africa. It protects domestic, farm, and wild animals from cruelty and neglect across the Upper Highway area and surrounding communities. The organisation provides veterinary services, rescue operations, outreach programs, and humane education. Known for its large volunteer base and public fundraising efforts.

Koeberg Alert Alliance is a Cape Town-based civil society group advocating against nuclear power and for sustainable energy in South Africa. Koeberg Alert Alliance (KAA) is a civil society organisation advocating against nuclear energy and promoting renewable alternatives. Based in Cape Town, KAA monitors the operations of the Koeberg Nuclear Power Station and lobbies for environmental transparency, public safety, and community awareness. They organise protests, publish reports, and collaborate with environmental watchdogs. Notable for their citizen-led activism and energy policy influence.

La Leche League South Africa is a nonprofit that offers breastfeeding support and education through volunteer-led mother-to-mother counselling. La Leche League South Africa is part of the international La Leche League network, dedicated to supporting breastfeeding through mother-to-mother education. It operates nationally via volunteer leaders, offering personal consultations, support groups, telephone helplines, and online resources. Its core mission is to promote informed, natural infant feeding practices and maternal empowerment.

Langebaan Animal Care offers sterilisation, rescue, and outreach services to improve domestic animal welfare in the Western Cape. Langebaan Animal Care (LAC) is a registered NPO in the Western Cape committed to the care and welfare of domestic animals in and around Langebaan. Founded in 2001, the organisation provides sterilisation programs, veterinary care, adoptions, education, and outreach services to low-income communities. LAC is known for its proactive approach in reducing animal overpopulation and improving animal welfare.

Leratong Community Hub is a Gauteng-based community center supporting youth, families, and entrepreneurs with inclusive development programs. Leratong Community Hub is a nonprofit development centre in Krugersdorp, Gauteng, offering integrated community services including youth development, entrepreneurship training, health education, and social welfare programs. The hub serves as a safe space for children, women, and families in need and collaborates with local government and businesses for impact-driven initiatives.

Lesedi Community Centre is a Bloemfontein-based NPO providing feeding, youth, and skills programs to uplift vulnerable communities. Lesedi Community Centre is a faith-based nonprofit organization operating in Heidedal, Bloemfontein. It provides holistic community support through feeding schemes, youth programs, skills training, and early childhood development. The centre partners with churches, schools, and social services to uplift marginalized families and individuals.

Life Community Radio 105FM is a faith-based radio station broadcasting inspirational content to communities in East London, Eastern Cape. Life Community Radio 105.0FM is a community Christian radio station based in East London, Eastern Cape. It broadcasts local news, spiritual programs, talk shows, and music to communities across Buffalo City and surroundings. Its mission is to inspire, inform, and uplift through values-driven content and community partnerships.

LIFE Community Services is a George-based NGO supporting vulnerable children and families through holistic Christian-based development programs. LIFE Community Services is a Christian nonprofit in George, Western Cape, serving vulnerable children and families. Their programs include feeding schemes, after-school care, skills training, and psychosocial support. Founded in 2001, LIFE has become a key social partner in the region with a mission to offer hope and transformation through love, faith, and service.

Living With Cancer SA is a nonprofit that offers education, support, and advocacy for individuals affected by cancer in South Africa. Living With Cancer SA is a South African non-profit organization dedicated to supporting people affected by cancer. It provides educational resources, psychosocial support, patient advocacy, and wellness guidance. The platform connects patients, survivors, and caregivers, fostering awareness and support for all cancer types. They focus on empowering individuals with knowledge and tools to navigate cancer journeys.

Love Story is a Gqeberha-based nonprofit that feeds and restores dignity to vulnerable and homeless individuals through daily outreach and support. Love Story is a Port Elizabeth-based NPO focused on feeding, clothing, and restoring dignity to the homeless and vulnerable. Their services include daily feeding schemes, clothing distribution, emergency relief, and community upliftment. Since its founding in 2012, Love Story has partnered with churches, volunteers, and corporate donors to reach marginalized individuals with acts of love and service.

Love to Give is a nonprofit in Stellenbosch that delivers school nutrition, education support, and skills training in Kayamandi. Love to Give is a nonprofit organization based in Kayamandi, Stellenbosch, focused on child nutrition, education support, and enterprise development. It provides daily meals to over 2000 learners, skills development for parents, and job readiness training. Established in 2005, the NGO addresses food insecurity and poverty through practical, long-term community engagement.

loveLife is a national youth NGO offering health education and empowerment programs across South Africa since 1999. loveLife is one of South Africa’s largest youth-focused NGOs promoting health, leadership, and HIV prevention. Founded in 1999, it operates nationwide with youth centers, schools, and media campaigns. Programs address sexual health, gender-based violence, mental health, and life skills. Its peer educator model (groundBREAKERs) has impacted millions of young South Africans.

MSH South Africa is part of a global nonprofit improving public health through systems strengthening, HIV/TB support, and policy implementation. Management Sciences for Health (MSH) is a global nonprofit dedicated to strengthening health systems and improving public health outcomes. The South Africa office supports health policy implementation, pharmaceutical management, HIV/AIDS care, TB control, and capacity development. MSH partners with governments and civil society to promote universal health coverage and systems resilience.

Mandela House in Soweto is a historic museum preserving the life and legacy of Nelson Mandela through exhibitions and education. Mandela House, located in Soweto, is the former home of Nelson Mandela and now a heritage site and museum managed by the Nelson Mandela Foundation. It preserves the legacy of Madiba through guided tours, educational exhibitions, and community engagement. As a cultural institution, it plays a key role in South Africa’s historical memory and tourism sector.

Masemola Charity Foundation offers feeding schemes, education supplies, and skills training to disadvantaged communities in Gauteng. Masemola Charity Foundation is a nonprofit based in Midrand, South Africa, that empowers disadvantaged communities through food aid, education support, and skills training. They run feeding programs, donate school supplies, and host workshops aimed at sustainable livelihoods. The foundation is community-driven and collaborates with local businesses to expand its reach.

Masimanyane Women's Rights International advocates for gender justice, GBV support, and women’s empowerment across South Africa and globally. Masimanyane Women's Rights International is a global NGO headquartered in East London, South Africa, advocating for women's rights and gender justice. Founded in 1995, it offers support to survivors of gender-based violence, HIV/AIDS services, and legal aid. Masimanyane also conducts research and policy advocacy at local and international levels.

Masinyusane is an education-focused nonprofit providing academic support and sponsorships for students in the Eastern Cape. Masinyusane is a nonprofit organization based in East London, Eastern Cape, working to uplift disadvantaged learners and schools through high-impact educational support. They provide tutoring, infrastructure improvements, and tertiary education sponsorships. Their mission is to unlock youth potential by empowering students academically and socially.

MSF South Africa provides humanitarian medical assistance in crises while supporting regional health advocacy and education. Médecins Sans Frontières (Doctors Without Borders) is a global humanitarian organization that delivers emergency medical care in conflict zones and underserved areas. The South African office supports local and regional health responses, public education, and advocacy. MSF is known for its independence, impartiality, and rapid response to health crises including epidemics and natural disasters.

Mercy Corps South Africa supports youth employment, entrepreneurship, and humanitarian aid through development programs and partnerships. Mercy Corps is a global humanitarian organization that works in the world’s toughest places to alleviate suffering, poverty, and oppression. In South Africa, the organization focuses on youth employment, entrepreneurship, and resilience-building among marginalized populations. Mercy Corps partners with government, private sector, and civil society to support systemic change through local solutions.

Midrand SPCA protects animals through rescue, care, rehoming, and cruelty prevention across the Midrand region. Midrand SPCA is a nonprofit animal welfare organization committed to preventing cruelty and promoting the humane treatment of animals. It offers rescue, rehabilitation, rehoming, and education services. Serving the Midrand community and surrounding areas, the SPCA enforces animal protection laws and encourages responsible pet ownership.

MIET AFRICA promotes inclusive education, HIV/AIDS prevention, and youth development across Southern Africa. MIET AFRICA is a regional NGO dedicated to improving the lives of children and youth through education and development programs. Founded in 1996, MIET has led initiatives in life skills, HIV/AIDS prevention, inclusive education, and psychosocial support. It operates in South Africa and SADC countries, promoting quality education systems for all.

Missing Children SA works with police and the public to locate missing children and raise awareness on child safety nationwide. Missing Children South Africa is a nonprofit that assists in tracing and recovering missing children across South Africa. Established in 2007, it works closely with SAPS, media, and communities to rapidly disseminate alerts and coordinate efforts. The organization also raises awareness on child safety and prevention of abductions and trafficking.

Movember SA promotes men’s health awareness and funds cancer and mental health programs through national campaigns. Movember South Africa is part of the global Movember Foundation, focused on men's health awareness including prostate cancer, testicular cancer, mental health, and suicide prevention. Each November, they run fundraising and awareness campaigns encouraging men to grow moustaches and start conversations around health. Movember funds local programs and research aimed at improving health outcomes for South African men.

MSI South Africa offers reproductive health services including family planning, abortion care, and STI testing across the country. MSI Reproductive Choices South Africa (formerly Marie Stopes) is a leading provider of sexual and reproductive health services. Operating over 10 centers across South Africa, it offers services such as contraception, safe abortion care, STI testing, and pap smears. Founded in the early 1990s, MSI advocates for reproductive rights and safe, non-judgmental health care access.

Muslim Aid SA provides food relief, disaster response, and development programs to vulnerable communities across South Africa. Muslim Aid South Africa is part of the global Muslim Aid family, providing humanitarian aid and sustainable development support. Their services include emergency response, food distribution, water and sanitation, and education programs for underserved communities. Based in Durban, they operate nationally with a strong focus on dignity and empowerment.

Muslim Hands SA provides humanitarian aid including education, food, orphan care, and water support to vulnerable communities. Muslim Hands is an international aid agency working in over 30 countries, with its South African office based in Cape Town. It delivers aid through water projects, hunger relief, orphan care, education, and seasonal programs such as Qurbani and Ramadan food distributions. Muslim Hands South Africa empowers local communities through zakat-driven charity and humanitarian efforts.

NACOSA supports community HIV/AIDS and TB programs through funding, training, and advocacy across South Africa. NACOSA (Networking HIV & AIDS Community of Southern Africa) is a network of over 1,500 civil society organizations working together to fight HIV, AIDS, TB, and gender-based violence. NACOSA supports community systems, grants management, capacity building, and policy advocacy. Their focus includes key populations such as women, youth, and people living with HIV.

Natural Justice defends community land and environmental rights through legal empowerment and advocacy across South Africa and Africa. Natural Justice is a legal and environmental nonprofit organization that supports communities in protecting their land, resources, and rights. Founded in 2007, the NGO combines legal empowerment with advocacy to safeguard indigenous and environmental justice across Africa. They operate from offices in Cape Town and internationally across several African countries.

Natural Selection Foundation supports wildlife conservation and community-based environmental protection across Southern Africa. The Natural Selection Foundation is dedicated to wildlife conservation, community engagement, and habitat protection in Africa. It supports long-term projects that ensure the sustainability of species and ecosystems, often working alongside ecotourism partners. Operating from Cape Town, the foundation funds and manages conservation and education efforts across Southern Africa.

NGOConnectSA is a digital platform enabling South African nonprofits to connect, share resources, and grow their impact. NGOConnectSA is an online hub that supports NGOs, NPOs, and CSI initiatives in South Africa. The platform offers networking, visibility, and resource sharing for nonprofits, social enterprises, and donors. It also provides training, consultancy, and capacity development to strengthen civil society organizations across sectors.

Not I But We is a community-focused nonprofit co-developing solutions in food, education, and dignity in Cape Town. Not I But We is a grassroots organization based in Cape Town focused on mutual aid, social justice, and community development. The organization partners with informal settlement residents to co-create solutions in areas such as food security, education, and housing. Founded in response to systemic inequality, Not I But We emphasizes dignity, equity, and participatory action.

Oceans Alive Conservation Trust protects marine ecosystems through education, restoration, and sustainable ocean programs in South Africa. Oceans Alive Conservation Trust is a marine conservation organization dedicated to protecting South Africa’s ocean ecosystems. It runs community-based ocean literacy, sustainable fishing advocacy, and biodiversity restoration projects. Based in Kalk Bay, Cape Town, the NGO works with local fishers, youth, and scientists to foster ocean stewardship.

One Ummah Charity provides food relief, disaster support, and community upliftment services in South Africa and abroad. One Ummah Charity is a South African nonprofit organization committed to humanitarian assistance, focusing on food distribution, disaster relief, education support, and poverty alleviation. Operating from Johannesburg, it serves vulnerable communities locally and internationally. The organization emphasizes Islamic values of charity and regularly runs Ramadan, Qurbani, and emergency relief programs.

Operation Hunger addresses food insecurity in South Africa through feeding programs, gardens, and nutrition education. Established in 1980, Operation Hunger is a well-known nonprofit in South Africa that combats hunger and malnutrition in vulnerable communities. The organization provides food parcels, nutritional education, and sustainable food gardens. Based in Cape Town, Operation Hunger has impacted over 2.4 million lives through feeding schemes and resilience-building programs.

Pact South Africa empowers communities with health and development programs targeting HIV, children, and system resilience. Pact South Africa is the regional office of Pact, a global nonprofit that partners with local communities to build resilient and healthy societies. Their South African programs focus on HIV/AIDS prevention, child protection, capacity building, and health system strengthening. Pact works closely with government and civil society to address social and public health challenges.

PakSA supports the Pakistani diaspora in South Africa with cultural, social, and humanitarian services. Pakistan Association South Africa (PakSA) represents the Pakistani diaspora, providing social, cultural, and humanitarian services. It engages in community upliftment projects such as food drives, health clinics, legal support, and interfaith dialogue. The organization fosters integration while promoting Pakistani culture and values across South Africa.

Passion To Serve is a faith-based NPO offering food, clothing, orphan care, and life training to communities in South Africa. Passion To Serve is a Christian faith-based NPO providing food, clothing, education support, and spiritual care to underprivileged families. Based in Boksburg, Gauteng, the organization runs outreach programs in informal settlements, orphan care, and life skills training. It aims to serve with compassion and faith-driven empowerment.

The Peace Centre promotes peacebuilding, restorative justice, and leadership among youth and communities in Cape Town. The Peace Centre is a nonprofit based in Cape Town that promotes peacebuilding, social justice, and conflict transformation. Founded in 1985, it works with youth, schools, and communities through training, dialogues, and advocacy. The organization addresses violence prevention, restorative justice, and leadership development in under-resourced communities.

Peace Parks Foundation develops and supports large-scale conservation areas across southern Africa promoting biodiversity and peace. Peace Parks Foundation is a transboundary conservation NGO dedicated to restoring and preserving large ecosystems across southern Africa. Founded in 1997 by Dr. Anton Rupert, Nelson Mandela, and Prince Bernhard of the Netherlands, the organization supports the creation of peace parks, biodiversity conservation, and wildlife economies. It operates across multiple African countries in partnership with governments and communities.

PEP empowers low-income communities through participatory planning, urban development, and housing support in Cape Town. PEP is a Cape Town-based nonprofit committed to inclusive urban development through participatory planning and capacity building. They assist low-income communities in securing land, improving housing, and engaging government for sustainable development. Their work focuses on co-production of knowledge and community-led planning in informal settlements.

Pretoria Dog Rescue saves and rehomes neglected dogs in Gauteng while promoting responsible pet care. Pretoria Dog Rescue is a nonprofit animal rescue organization that focuses on rescuing, rehabilitating, and rehoming abandoned and abused dogs. Operating in Pretoria and surrounding areas, the organization relies on foster networks, donations, and community volunteers to provide shelter and care. They promote responsible pet ownership and offer sterilization support.

Project Flamingo provides timely breast cancer surgeries and emotional support to underserved patients in Cape Town. Project Flamingo is a Cape Town-based nonprofit focused on timely breast cancer treatment for underserved patients. Founded in 2010, it facilitates additional surgical lists, psychosocial support, and care packs for public health system patients. Project Flamingo bridges gaps in access to cancer care and advocates for equitable oncology services in South Africa.

The Prostate Cancer Foundation promotes awareness, education, and treatment support for prostate cancer across South Africa. The Prostate Cancer Foundation of South Africa is a nonprofit dedicated to raising awareness, supporting research, and improving diagnosis and treatment of prostate cancer. Founded in 2005, it collaborates with medical professionals and provides resources for patients, families, and healthcare workers across South Africa.

Raising Hope SA empowers people with disabilities in the Western Cape through assistive devices and inclusive support services. Raising Hope South Africa is a nonprofit organization in George that supports people with disabilities and chronic conditions. It provides assistive devices, support groups, public education, and community-based outreach. The organization empowers individuals through accessible resources and advocacy.

READ Educational Trust promotes literacy in South Africa through reading programs, teacher training, and learner support. READ Educational Trust is a South African NGO that promotes literacy and education through teacher training, learner support, and reading programs. Founded in 1979, it partners with government and schools to improve education outcomes, especially in under-resourced communities.

Rebirth Dance Company empowers youth in Johannesburg through dance, arts education, and social upliftment. Rebirth Dance Company is a Johannesburg-based nonprofit that uses dance as a tool for social change and empowerment. It focuses on youth development, education through arts, and community upliftment via creative expression and training programs.

Restore With Mother Nature promotes environmental restoration and youth sustainability leadership in South Africa. Restore With Mother Nature is an environmental nonprofit focused on nature restoration, sustainability education, and community eco-projects. Based in Durban, it encourages tree planting, youth environmental leadership, and conservation awareness in local communities.

Right to Care delivers health programs to combat HIV, TB, and related diseases across South Africa. Right to Care is a South African non-profit healthcare organization that supports and delivers prevention, care, and treatment services for HIV, TB, and related diseases. Founded in 2001, the organization works in partnership with government to strengthen public health systems across South Africa.

Rise Against Hunger Africa combats hunger through meal packaging and sustainable food security programs. Rise Against Hunger Africa is part of a global movement to end hunger. Based in Aeroton, Johannesburg, it engages in meal packaging, food distribution, and sustainable development programs. Since 2009, it has mobilized volunteers and partners to combat food insecurity across South Africa.

Rise Up Against Domestic Based Violence supports GBV survivors through advocacy and outreach in South Africa. Rise Up Against Domestic Based Violence is a Western Cape-based nonprofit focused on advocacy, support services, and awareness for survivors of gender-based violence. It offers counseling, outreach programs, and public education to empower affected individuals and communities.

Robberg Nature Reserve is a scenic conservation area offering hiking, wildlife, and education in Plettenberg Bay. Robberg Nature Reserve, managed by CapeNature, is a protected coastal reserve located in Plettenberg Bay. It promotes conservation, environmental education, ecotourism, and community involvement. Visitors can enjoy hiking trails, marine wildlife, and geological landmarks.

SARABI Paws With A Cause rescues and rehabilitates neglected animals in Gauteng, promoting pet welfare. SARABI Paws With A Cause is an animal welfare nonprofit based in Gauteng. It rescues, rehabilitates, and rehomes abused and neglected animals. The organization relies on donations and volunteers to carry out its mission and spread awareness on responsible pet ownership.

Save the Children South Africa supports education, health, and protection for vulnerable children across the country. Save the Children South Africa is part of the global Save the Children movement. Since 2013, it has worked to ensure that every child in South Africa survives, learns, and is protected. Programs focus on education, health and nutrition, child protection, and humanitarian relief across multiple provinces.

Sinakekele Children supports abandoned and orphaned children in KwaZulu-Natal through fostering and holistic care. Sinakekele Children is a faith-based nonprofit organization based in KwaZulu-Natal. It provides holistic care to abandoned and vulnerable children through fostering, adoption support, and long-term residential care. The organization has operated since 2003, offering hope and healing to children in need.

Small Projects Foundation promotes health, education, and development in communities across Eastern Cape. Small Projects Foundation is a development NGO founded in 1988 in the Eastern Cape. It focuses on health promotion, education, and community empowerment. It collaborates with local government, communities, and international donors to implement sustainable grassroots development projects.

Smile Foundation provides surgery and care for children with facial conditions across South Africa. Smile Foundation is a South African NGO that assists children with facial abnormalities, including cleft lips and palates, burn wounds, and craniofacial conditions. Founded in 2000, the organization partners with government hospitals to provide life-changing reconstructive surgery and post-operative care.

Sonke Gender Justice works to promote gender equality and prevent violence through advocacy and education in South Africa. Sonke Gender Justice is a nonprofit based in Cape Town that advocates for gender equality and human rights. Since 2006, it has worked across Africa on gender-based violence prevention, legal advocacy, and social justice education. Sonke collaborates with communities, governments, and other organizations to promote systemic change.

SAEON is a research network monitoring South Africa’s ecosystems for sustainability and climate resilience. SAEON is a long-term environmental observation and research network funded by the Department of Science and Innovation. Established in 2002, it monitors ecosystems over extended timeframes to inform decision-making in climate change, biodiversity, and sustainability. SAEON operates nodes across South Africa for terrestrial and marine research.

SANAC leads South Africa’s response to HIV, TB, and STIs through multi-sectoral coordination and advocacy. SANAC is a multi-sectoral body established in 2002 to coordinate the national response to HIV, TB, and STIs. It works with government departments, civil society, and development partners to drive policy, advocacy, and program implementation. SANAC leads the development of South Africa's National Strategic Plans on HIV, TB, and STIs.

SANZAF distributes Zakah and supports education, food security, and empowerment in Muslim and broader communities. SANZAF is a faith-based nonprofit that facilitates the collection and distribution of Zakah and other Islamic charitable contributions. Founded in 1974, SANZAF provides social relief, education bursaries, food security, and skills development initiatives across South Africa’s Muslim and vulnerable communities.

SANGOCO is a national coalition promoting civil society development, advocacy, and nonprofit sector unity in South Africa. SANGOCO was established in 1995 as a coalition to coordinate South Africa's civil society organizations in post-apartheid development. It advocates for a strong nonprofit sector and promotes accountability, participation, and social justice through policy engagement and advocacy.

Southern Africa Trust advances inclusive development and regional integration through partnerships and advocacy across SADC. The Southern Africa Trust is a nonprofit organization that supports regional integration and poverty reduction through inclusive dialogue and partnerships. Founded in 2005, it engages civil society, governments, and regional bodies across SADC to amplify citizen voices and drive equitable policy.

SACHIF empowers vulnerable children through education, food security, and child protection programs in Southern Africa. Southern African Children First (SACHIF) is a nonprofit organization based in Johannesburg focused on protecting and empowering vulnerable children. Founded in 2004, it offers child protection, early childhood development, food security, and psychosocial support services in Gauteng and surrounding areas.

SANGONeT empowers nonprofits with digital tools, advocacy, and resources to strengthen civil society in Southern Africa. Established in 1987, SANGONeT is a civil society and ICT nonprofit that supports and strengthens NGOs in Southern Africa through technology, training, and advocacy. It also runs NGO Pulse, a portal promoting sector news, vacancies, and funding opportunities.

SPANA operates in South Africa offering veterinary aid and education to improve working animal welfare. SPANA (Society for the Protection of Animals Abroad) is an international charity operating in South Africa to provide veterinary care, animal welfare education, and community outreach for working animals. Its work includes mobile clinics and training programs to improve the health and treatment of animals used for labor.

Terrafrica promotes sustainable land use across Africa through policy advocacy and ecosystem restoration initiatives. Terrafrica is a pan-African partnership initiative that supports sustainable land and ecosystem management to combat land degradation. While not headquartered specifically in South Africa, it collaborates with South African institutions on environmental and policy programs for land restoration.

The Cradle of Hope offers safe housing and empowerment services for vulnerable women and children in South Africa. The Cradle of Hope is a registered nonprofit in Krugersdorp offering transitional housing and empowerment programs for women and children affected by abuse, poverty, and homelessness. Established in 2007, it provides job readiness training, food aid, counseling, and shelter for vulnerable groups in Gauteng.

The Hives empowers rural South African communities through education, youth development, and HIV/AIDS support programs. The Hives Services Organization is a nonprofit community-based organization based in Empangeni, KwaZulu-Natal. It focuses on education, gender-based violence awareness, youth development, HIV/AIDS education, and community empowerment programs. Founded in 2004, Hives serves under-resourced rural communities with outreach, workshops, and skills training.

Reach For A Dream brings joy and support to children with life-threatening illnesses across South Africa. Founded in 1988, The Reach For A Dream Foundation fulfills the dreams of children between the ages of 3 and 18 who are diagnosed with life-threatening illnesses. Operating nationally in South Africa, the organization provides emotional support and uplifting experiences to bring hope and joy during challenging times.

The Society for Animals in Distress rescues and rehabilitates animals while providing outreach veterinary care in South Africa. Established in 1958, The Society For Animals In Distress is a leading animal welfare NGO located in Midrand, Gauteng. It provides veterinary services, outreach clinics, education programs, and emergency rescue for domestic animals in poor communities.

SOS Africa empowers disadvantaged South African children through education sponsorship and mentorship programs. The SOS Africa Western Cape Trust is a South African education NGO that provides scholarships, mentorship, and holistic support to underprivileged children. Founded in 2003, the trust operates mainly in the Western Cape and partners with schools to uplift disadvantaged learners.

South African Red Cross Society provides disaster relief, health education, and humanitarian support nationwide. The South African Red Cross Society is a major humanitarian NGO dedicated to disaster response, health education, and community support across South Africa. Established in 1921, it is affiliated with the International Red Cross and offers services like first aid training, disaster relief, and social development.

The Sozo Foundation empowers Cape Town youth through education, skills development, and mentorship programs. The Sozo Foundation is a nonprofit organization based in Cape Town, South Africa, focused on youth development and education in under-resourced communities. Established in 2011, it offers skills training, tutoring, leadership programs, and job readiness support for young people in the Vrygrond area.

The Viva Foundation transforms informal settlements in Pretoria through education, healthcare, and skills training. The Viva Foundation is a community-driven NGO working in Mamelodi East, Pretoria. Founded in 2008, it focuses on community upliftment through education, feeding schemes, support for abused women and children, and skills development. The Viva Village model transforms informal settlements by providing sustainable education, healthcare, and income-generation programs.

Thembalitsha Foundation provides healthcare, education, and empowerment programs to transform lives in South Africa. The Thembalitsha Foundation is a nonprofit that supports vulnerable communities in the Western Cape through health care, education, and training programs. Founded in 1997, the organization operates seven projects including clinics, early childhood development, and caregiver training for orphans and vulnerable children.

Two Oceans Aquarium Foundation delivers marine conservation, turtle rehab, and environmental education in Cape Town. The Two Oceans Aquarium Foundation is a public benefit organization promoting marine conservation and ocean education in South Africa. Established alongside the Two Oceans Aquarium, it provides environmental education, ocean research, turtle rescue and rehabilitation, and outreach programs.

UNAIDS supports HIV/AIDS prevention and treatment initiatives in South Africa through partnerships and policy guidance. UNAIDS South Africa works as part of the global Joint United Nations Programme on HIV/AIDS to support national response strategies. It partners with government and civil society to reduce new infections, improve access to treatment, and promote human rights.

UNICEF South Africa works to advance children's rights and well-being through health, education, and protection programs. UNICEF South Africa is part of the global UN agency focused on child welfare, working to improve the lives of children through education, health, nutrition, and protection services. Active since 1994 in the region, UNICEF collaborates with government and partners to uphold children's rights and well-being.

UNIDO supports sustainable industrial growth in South Africa through innovation and public-private partnerships. UNIDO is a specialized agency of the United Nations focused on promoting inclusive and sustainable industrial development. In South Africa, UNIDO works with government and private sector partners to implement industrial development programs, foster innovation, and support environmental sustainability and energy efficiency initiatives. The agency has a regional office in Pretoria and collaborates on multiple developmental projects across Southern Africa.

Volunteer Wildfire Services is SA’s top volunteer firefighting NGO protecting forests and communities from wildfires. Established in 1999, Volunteer Wildfire Services is South Africa’s largest volunteer firefighting organization. Based in the Western Cape, VWS provides trained, equipped and committed volunteer crews that assist with combating wildfires in national parks, forests, and mountainous regions. They also run awareness campaigns and fire prevention education.

WaterAid South Africa ensures access to clean water and sanitation in communities and schools across the country. WaterAid South Africa is part of the global WaterAid federation that aims to ensure everyone, everywhere has access to clean water, sanitation, and hygiene. Working with local partners, WaterAid SA focuses on rural water infrastructure, hygiene education, policy advocacy, and WASH services in schools and communities.

WBH College offers affordable, accredited business and tech training to empower underprivileged youth in South Africa. WBH College is a registered nonprofit further education institution located in Durban, South Africa. It provides affordable, accredited tertiary education with a focus on business, administration, and technology. The college serves underprivileged students, equipping them with practical skills for employment.

We The People is a nonprofit building participatory democracy in South Africa through civic education and accountability. We The People - South Africa is a civic education and public accountability nonprofit focused on building a participatory democracy in South Africa. Founded in 2020, the organization works to empower citizens with knowledge of their rights and the tools to hold leaders accountable. Through innovative programs, workshops, and digital campaigns, We The People aims to rebuild trust between government and communities.

Wild Impact is a conservation nonprofit based in Cape Town promoting wildlife protection and environmental sustainability. Wild Impact is a South African conservation nonprofit dedicated to wildlife protection, environmental education, and ecological sustainability. Operating in the Western Cape, the organization collaborates with schools, communities, and conservationists to drive long-term change. Its programs include wildlife rescue, anti-poaching training, and youth-led conservation education.

Wildlife ACT is a KZN-based NGO focused on endangered species monitoring and conservation volunteering in South Africa. Wildlife ACT is a nonprofit organization working in conservation and wildlife monitoring across protected areas in KwaZulu-Natal. Established in 2008, the organization partners with parks and reserves to support endangered species, such as African wild dogs and rhinos. Volunteers join fieldwork teams to contribute directly to conservation impact on the ground.

WESSA is a historic environmental NGO in South Africa promoting conservation and sustainability through national programs. Founded in 1926, the Wildlife and Environment Society of South Africa (WESSA) is one of the country’s oldest and most respected environmental organizations. WESSA works to promote public participation in environmental conservation and sustainable development. It runs national programs in eco-schools, eco-tourism, water conservation, and environmental policy.

Wola Nani supports people living with HIV/AIDS in Cape Town through care, empowerment, and artisan training. Wola Nani is a Cape Town-based nonprofit established in 1994 to support people living with HIV/AIDS. The organization provides psychosocial support, home-based care, income-generation projects, and health education. Wola Nani also offers artisan training for women, helping them create and sell handmade crafts for sustainable livelihoods.

WAMY South Africa promotes Muslim youth development, education, and humanitarian aid across Gauteng. World Assembly of Muslim Youth (WAMY) South Africa is part of an international organization dedicated to the education, development, and empowerment of Muslim youth. Founded to promote Islamic values and social responsibility, WAMY SA organizes youth development programs, humanitarian aid, and religious education initiatives throughout the country. It focuses on creating a positive impact in underprivileged communities, especially in Gauteng and surrounding regions.

World Vision South Africa fights poverty and injustice through education, health, and community development. World Vision South Africa is a Christian humanitarian organization that partners with children, families, and communities to tackle the causes of poverty and injustice. Operating in multiple provinces, World Vision focuses on education, health, child protection, and clean water access. It is part of the global World Vision network and has been active in South Africa for decades.

WWF South Africa promotes environmental conservation and sustainable living across the nation. WWF South Africa is a branch of the global conservation organization World Wide Fund for Nature. Established in 1968, it works to inspire South Africans to live in harmony with nature through environmental protection, biodiversity conservation, and climate change mitigation. WWF-SA leads research, policy, and community-driven conservation efforts across the country.

Youth Alive Ministries supports and empowers youth in Johannesburg through mentorship, education, and spiritual growth. Youth Alive Ministries is a Christian nonprofit in Johannesburg dedicated to empowering youth through mentorship, spiritual development, education, and community outreach. Since its founding, the organization has worked to uplift disadvantaged youth across Gauteng by providing safe spaces, life skills, and biblical guidance.