The YMCA in Uganda was founded in 1959. It has six main branches, including Kampala YMCA. Other branches are in Jinja, Mukono, Mbale, Mbarara, Kasese.

The first mention of a YMCA in Uganda was made in a 1913 report of the World Alliance. The matter rested until 1947, when the World Alliance of YMCAs in Geneva sent Dr. George Haynes to investigate the possibilities for YMCAs in Africa. He met in Uganda E. M. K. Mulira. as a result, the present site for the Headquarters, YMCA Kampala Branch and YMCA Comprehensive Institute , was chosen.

All YMCA activities in Uganda are coordinated by the National Secretariat headed by the National Executive Director.

The Secretariat runs a computer school which offers skilling programs such as computer applications, computer maintenance course and electronics courses its also runs a Driving school.