Mbarara High School (MHS), is a boys-only boarding middle and high school located in the city of Mbarara, in Mbarara District in Western Uganda.

It was established in 1911 by Anglican, Christian missionaries affiliated with the Church of England. Mbarara High School is the oldest secondary school in Western Uganda. It has both ordinary level and advanced level classes. The land on which the school was built is owned by Ankole Diocese, of the Church of Uganda. While the church has ownership and control of the school, the Uganda Government, through the Ministry of Education, contributes to the school's budget. The Kumanyana protest movement of the 1940s, which demanded equality for the Bairu people of Ankole with the Hima, had its roots at the school.